Cardiology and Cardiovascular Medicine Research

Cardiac Hypertrophy

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Cardiac hypertrophy is defined as an increase in the size of the heart caused by an increase in the size of the cardiomyocytes therein, which is achieved by an increase in the number of sarcomeres, a basic unit of a muscle's cross-striated myofibril. Cardiac hypertrophy is caused by hemodynamic overload, which includes pressure overload (PO) caused by aortic stenosis and high blood pressure, and volume overload (VO) caused by valvular insufficiency, chronic myocardial infarction, arteriovenous shunt, and pregnancy. PO causes “concentric” hypertrophy, characterized by increased ventricular wall thickness and little chamber dilation, where parallel addition of sarcomeres increases the size of cardiomyocytes in both minor and major axes. In contrast, VO results in “eccentric” hypertrophy, characterized by increased ventricular volume with little increase in the wall thickness, where serial addition of sarcomeres increases the size of cardiomyocytes primarily by elongation.

Related Conferences

7^th World Cardiothoracic Meeting March 29-30, 2016 Atlanta, USA; Echo Cardiography Conference June 06-07, 2016 London, UK; Ischemic Heart Diseases Conference May 12-13, 2016 Chicago, USA; 8^th Global Cardiologists Annual Meeting July 18-20, 2016 Berlin, Germany; Annual Conference on Atherosclerosis July 11-12, 2016 Philadelphia, USA; Drug Discovery and Therapy World Congress May 11-14, 2016, Boston, USA; 7^th International Conference on Drug Discovery and Therapy, February 15-18, 2016 Dubai, UAE; Arrhythmias & the Heart: A Cardiovascular Update, February 12–16, 2016, Riyadh, Saudi Arabia; 16^th Annual International Symposium on Congenital Heart Disease, February 13–16, 2016, St. Petersburg, USA; Cardiovascular Conference at Snowbird, February 12-15, 2016, Snowbird, Utah; Korean Cardiology Related Societies Joint Scientific Congress, April 15-16, 2016, Daegu, Korea.